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Revolutionizing Chemical Manufacturing

Bio-powered, planet-scale

The Bioforge is an entirely new manufacturing platform that bypasses the limitations of traditional processes. Leveraging a first of its kind combination of engineered enzymes and metal catalysts, sustainable feedstocks are converted into essential materials with no harmful byproducts and minimal emissions.

It all starts with bio-based feedstocks.

Circular Feedstock Read More

Our process starts with simple, abundant, and inexpensive bio-based feedstocks. Dextrose, water, and compressed air is continuously pumped into our enzyme oxidation reactor where our engineered enzymes begin the conversion process.

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Engineered enzymes begin the highly efficient conversion process.

Engineered Enzymes Read More

The use of computational design, rational design, and AI optimizes our enzymes, resulting in superior efficiency and sustainability across a diverse range of molecules. The development process includes generating AI-filtered smart libraries, high-throughput screening of thousands of enzyme variants, and fermentation to scale up production in large bioreactors. These engineered enzymes drive highly efficient, cell-free reactions at room temperature with low energy input.

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Engineered metal catalysts optimize throughput.

Heterogeneous Metal Catalysts Read More

By iterating advanced reaction technologies with modern separations techniques, we consistently achieve integrated yields of over 95%, and in some cases near unity. This is unheard of in traditional manufacturing processes. The Bioforge can efficiently convert raw materials directly into valuable products, addressing the inefficiencies of traditional methods with little to no carbon emissions and no hazardous waste.

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The result— high performing, cost competitive, sustainable products.

Product Read More

By iterating advanced reaction technologies with modern separations techniques, we consistently achieve integrated yields of over 95%, and in some cases near unity. This is unheard of in traditional manufacturing processes. The Bioforge can efficiently convert raw materials directly into valuable products, addressing the inefficiencies of traditional methods with little to no carbon emissions and no hazardous waste.

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Optimizing every step of the way

Solugen’s world-class research and development team includes a range of advanced technical capabilities that allows us to refine and optimize every aspect of the manufacturing process.

Our Capabilities

Analytic Chemistry

Our team utilizes a range of instruments, including UPLCs, GCs, ICP, TOF-MS, GCP, and NMR, to conduct routine analysis for established processes and develop new methods for analyzing molecules from emerging chemistries.

Chemical Synthesis

Synthesis pathways are developed to advance the production of new, promising molecules. This includes validating production feasibility, assessing cost and time impacts, and refining chemical properties based on application screenings to achieve optimal conditions for commercial production.

Strain Engineering

Genetic engineering techniques are employed to fine-tune microbial strains, optimizing their ability to produce enzyme catalysts used in our manufacturing processes.

AI and Machine Learning

Leveraging artificial intelligence and machine learning, we fine-tune complex chemical processes, optimize reaction yields, and improve product quality. This technology accelerates directed enzyme evolution by predicting the functional effects of multiple mutations and facilitates the design of DNA libraries for high-throughput screening. It also expedites the design of metal catalysts and enhances manufacturing operations.

Quality Control and Assurance

Rigorous quality control measures are put in place to ensure the consistency, purity, and excellence of our final products.

Product Development

Along the way, innovative products and applications for current and future chemistries are created and tested. This involves strategically orchestrating market research, ideation, prototyping, and testing to bridge the gap between innovative ideas and successful product commercialization.

Process Development

After new chemistries are synthesized, we translate them into scaleable engineering designs. This involves the design and scale up of new processes that are robust, clean, and enable high yields.

Bioflex Senior

The engineered enzymes used in our manufacturing process are produced at our Bioflex Senior fermentation plant. Named for its equipment flexibility, Bioflex can produce both intracellular and extracellular enzymes in bacteria, yeast, and filamentous fungi, enabling rapid and cost-effective scaling of new enzymes and processes.

Pilot Plant

Enzymes and metal catalysts are tested in our pilot plant to improve our understanding of the chemistry and kinetics of reactions on a commercial scale. We identify and address limitations observed at the bench-scale, ensuring successful transfer of information, learnings, and data to engineering and operations across various scales.

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